Growth failure resulting in short stature has a variety of causes. One uncommon cause of short stature relates to mutations in the aggrecan gene. This conditions runs in families in an autosomal dominant pattern and causes severe loss of height growth. Osteoarthritis often occurs in adulthood. Dr. Alexandrou is part of a team that now reports 3-year outcomes resulting from growth hormone treatment in children with this condition. She helped co-author the scientific report, which is being published in the Journal of the Endocrine Society (PubMed link to their publication). Briefly their results indicate that roughly 2.5 inches of additional growth were achieved without adverse effects. Studies to determine long-term outcomes are still needed. The publication highlights the importance of bringing children who are growing poorly to be evaluated by a pediatric endocrinologist to help determine the potential causes and to consider possible treatments.

Pediatric Research Day 2023 at the University of Iowa was held on the afternoon of April 7th, highlighting six speakers and multiple posters. The Division of Endocrinology and Diabetes was well represented. Faculty Dr. Cat Pinnaro gave a research talk entitled “Explaining phenotypic variability in Turner syndrome: Does X Mark the Spot”. Third year endocrinology fellow Dr. Alexander Tuttle gave an award-winning talk entitled “An Interactive E-Book Resource About Inpatient Pediatrics Diabetes Management for Medical Learners: Preliminary Results of a Pilot Study”. Dr. Graciela Parra Villasmil presented a research “data blitz” and poster entitled “Variability in glycemia measured by CGM in children and young adults with acute recurrent or chronic pancreatitis”. Importantly, these highlight our division’s ongoing efforts to improve the care of children with endocrine conditions.

We were graced today by a clinical grand rounds talk from Philippe Backeljauw, MD. Dr. Backeljauw is Professor at the University of Cincinnati Department of Pediatrics. He is also Director of their Pediatric Endocrine Fellowship Program and Director of the Cincinnati Center for Pediatric and Adult Turner Syndrome Care. He spoke at our Pediatric Grand Rounds. Dr. Backeljauw is an internationally recognized expert in the clinical care of patients with growth disorders and patients with Turner syndrome. He received his MD from the University of Ghent in Belgium, completed pediatric residency at Cleveland Clinic, and pediatric endocrinology fellowship at the University of North Carolina. He has published over 100 peer-reviewed manuscripts. Recently, he was instrumental in devising clinical practice guidelines related to Turner Syndrome via the International Turner Syndrome Consensus Group. Dr. Backeljauw spoke today on the “Clinical Management of Turner Syndrome”.